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Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen
Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 195-203 doi: 10.1007/s11684-012-0189-3
The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofenThe anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene.SDBT displayed more significant anti-inflammatory effects than CT.The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea
Keywords: ibuprofen solid dispersion physical mixture dissolution anti-inflammatory effect
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 216-226 doi: 10.1007/s11684-022-0920-7
Keywords: tsRNA biomarker hepatocarcinoma
Jianping Ye
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 139-145 doi: 10.1007/s11684-015-0377-z
Keywords: inflammation obesity cytokine energy expenditure insulin resistance
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 1, Pages 99-105 doi: 10.1007/s11783-013-0490-7
Keywords: estrogen microRNA (miRNA) microarray biomarker
Plasma transthyretin is a nutritional biomarker in human morbidities
Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 540-550 doi: 10.1007/s11684-022-0940-3
Keywords: lean body mass nutritional status transthyretin malnutrition inflammation amyloidosis
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 292-301 doi: 10.1007/s11684-020-0806-5
Keywords: bioactive hyaluronan lipopolysaccharide inflammatory cytokines TLR4 human macrophages
Biosensor-based assay of exosome biomarker for early diagnosis of cancer
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 157-175 doi: 10.1007/s11684-021-0884-z
Keywords: biosensor exosome cancer diagnosis
Changlin Cao, Jingxian Gu, Jingyao Zhang
Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 169-177 doi: 10.1007/s11684-017-0505-z
Keywords: soluble triggering receptor expressed on myeloid cells-1 infectious diseases diagnosis and prognosis biomarker
Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 723-735 doi: 10.1007/s11684-021-0905-y
Keywords: amyotrophic lateral sclerosis coronin-1a autophagy pathogenesis
Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 278-285 doi: 10.1007/s11684-016-0453-z
Keywords: iTRAQ secretome colorectal cancer TPM2
Sepsis biomarkers: an omics perspective
Xiao Liu, Hui Ren, Daizhi Peng
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 58-67 doi: 10.1007/s11684-014-0318-2
Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. This review describes currently available and novel sepsis biomarkers in the context of genomics, transcriptomics, proteomics, and metabolomics. The combination of these technologies can help refine the diagnosis of sepsis. This review paper serves as a reference for future studies that employ an integrated, multi-omics approach to disease identification.
Keywords: sepsis biomarker genomics transcriptomics proteomics metabolomics
U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen
Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang
Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 6, doi: 10.1007/s11783-016-0880-8
Keywords: miRNA Prostate Estradiol Nonmonotonic dose-response Estrogenicity Drosha
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 378-388 doi: 10.1007/s11684-021-0840-y
Keywords: severe Mycoplasma pneumoniae pneumonia children proteomics Fc fragment of the IgG-binding protein mechanistic target of rapamycin kinase inhibitor
Non-genetic mechanisms of diabetic nephropathy
Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu
Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 319-332 doi: 10.1007/s11684-017-0569-9
Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes mellitus patients and is characterized by thickened glomerular basement membrane, increased extracellular matrix formation, and podocyte loss. These phenomena lead to proteinuria and altered glomerular filtration rate, that is, the rate initially increases but progressively decreases. DN has become the leading cause of end-stage renal disease. Its prevalence shows a rapid growth trend and causes heavy social and economic burden in many countries. However, this disease is multifactorial, and its mechanism is poorly understood due to the complex pathogenesis of DN. In this review, we highlight the new molecular insights about the pathogenesis of DN from the aspects of immune inflammation response, epithelial–mesenchymal transition, apoptosis and mitochondrial damage, epigenetics, and podocyte–endothelial communication. This work offers groundwork for understanding the initiation and progression of DN, as well as provides ideas for developing new prevention and treatment measures.
Keywords: diabetic nephropathy immune inflammatory response epithelial–mesenchymal transition apoptosis mitochondrial
Current advances in the elimination of hepatitis B in China by 2030
Shuye Zhang, Fusheng Wang, Zheng Zhang
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 490-501 doi: 10.1007/s11684-017-0598-4
With its 78 million chronic carriers, hepatitis B virus (HBV) infection is still one of the leading public health challenges in China. Over the last two decades, China has made great progress on the prevention of HBV transmission through national vaccination programs. Zero transmission from mother to infant has been proposed as the current goal. Available anti-HBV therapy is efficacious in suppressing HBV replication; however, it fails to completely cure patients with chronic hepatitis B and even requires lifelong treatment. To reduce the costs and improve the efficacy, several trials have been recently conducted in China to optimize the current anti-HBV managements. Novel biomarkers were identified to predict treatment outcomes, and new promising treatment strategies were developed. Reports also indicate that coinfections of HBV with other hepatotropic viruses and human immunodeficiency virus are common in China and cause severe liver diseases, which should be recognized early and treated properly. Work is still needed to eliminate hepatitis B in China by 2030.
Keywords: HBV CHB biomarker functional cure coinfection
Title Author Date Type Operation
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen
Journal Article
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
Jianping Ye
Journal Article
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
Journal Article
Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
Journal Article
Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis
Changlin Cao, Jingxian Gu, Jingyao Zhang
Journal Article
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker
Journal Article
iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic biomarker
Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang
Journal Article
U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen
Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang
Journal Article
study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum biomarker
Journal Article
Non-genetic mechanisms of diabetic nephropathy
Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu
Journal Article